SCHEMBL3078810

SCHEMBL3078810

CC(CS(C)(=O)=[N+]([O-])N=O)c1ccc(Cl)nc1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.40
MAPT P10636 2/20 0.36
ALDH1A1 P00352 7/20 0.34
CYP2D6 P10635 1/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
PKM P14618 2/20 0.34
POLB P06746 1/20 0.34
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
CYP2C19 P33261 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12797842 0.81 SMN1; SMN2 (0.40) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1
SCHEMBL3073514 0.80 SMN1; SMN2 (0.38) SMN1; SMN2MAPTALDH1A1MEN1KMT2A
SCHEMBL13420882 0.77 MAPT (0.39) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1
SCHEMBL12797945 0.76 SMN1; SMN2 (0.39) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1
SCHEMBL12797900 0.73 SMN1; SMN2 (0.38) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1
SCHEMBL18222309 0.71 SMN1; SMN2 (0.33) SMN1; SMN2MAPTALDH1A1CYP2D6PKM
SCHEMBL12797935 0.69 SMN1; SMN2 (0.42) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1
SCHEMBL12797899 0.69 SMN1; SMN2 (0.37) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1
SCHEMBL12797901 0.69 SMN1; SMN2 (0.37) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1
SCHEMBL12797950 0.68 SMN1; SMN2 (0.40) SMN1; SMN2MAPTALDH1A1CYP2D6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1732895-B1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2016-11-16 EP disclosed
US-7897782-B2 [3-(6-Chloropyridin-3-yl)-2-methylpropyl](methyl)oxido- lambda 4-sulfanylidenecyanamide; aphidicides DOW AGROSCIENCES LLC (US) 2011-03-01 US disclosed
US-7834188-B2 Insecticidal N-substituted sulfoximines DOW AGROSCIENCES LLC (US) 2010-11-16 US disclosed
US-7829719-B2 Insecticidal N-substituted sulfoximines DOW AGROSCIENCES LLC (US) 2010-11-09 US disclosed
US-7795456-B2 Insecticidal N-substituted sulfoximines DOW AGROSCIENCES LLC (US) 2010-09-14 US disclosed
US-20100076032-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-25 US disclosed
US-7678920-B2 Insecticidal N-substituted sulfoximines DOW AGROSCIENCES LLC (US) 2010-03-16 US disclosed
US-20100063136-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-11 US disclosed
US-20100056578-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-04 US disclosed
US-20100056579-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-04 US disclosed
US-20050228027-A1 Insecticidal N-substituted sulfoximines CORTEVA AGRISCIENCE LLC 2005-10-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056579-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885ALDH1A1 3325/4885
US-20100076032-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885ALDH1A1 3325/4885
US-20100063136-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885ALDH1A1 3325/4885
US-20100056578-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885ALDH1A1 3325/4885
US-20050228027-A1 Insecticidal N-substituted sulfoximines GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885ALDH1A1 3325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.