Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.51 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalamide SCHEMBL27950892 | 0.89 | TSHR (1.00) | TSHRLMNAGAACES1CA1 | |
| SCHEMBL260727 | 0.89 | TSHR (1.00) | TSHRLMNAGAACES1CA1 | |
| Hydrochloric Acid SCHEMBL11203029 | 0.87 | TSHR (0.96) | TSHRLMNAGAACES1CA1 | |
| Hydrochloric Acid SCHEMBL27509957 | 0.85 | TSHR (0.92) | TSHRLMNAGAACES1CA1 | |
| Methyl Alcohol SCHEMBL27858599 | 0.85 | TSHR (0.92) | TSHRLMNAGAAMAPTCES1 | |
| SCHEMBL13265968 | 0.84 | TSHR (0.62) | TSHRLMNAGAAMAPTMEN1 | |
| SCHEMBL5696165 | 0.83 | TSHR (0.88) | TSHRLMNAGAACES1CA1 | |
| SCHEMBL3328543 | 0.82 | MAPT (0.79) | LMNAGAAMAPTMEN1KMT2A | |
| SCHEMBL4163474 | 0.82 | MAPT (0.79) | LMNAGAAMAPTMEN1KMT2A | |
| Acetic Acid SCHEMBL28100034 | 0.81 | TSHR (0.85) | TSHRLMNAGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | claimed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | claimed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | claimed |
| US-20040002521-A1 | Cyclopropanecarboxylic acid amide compound and pharmaceutical use thereof | AJINOMOTO CO. INC | 2004-01-01 | — | — | US | claimed |
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | disclosed |
| EP-1844020-B1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS | EXELIXIS INC (US) | 2017-09-06 | — | — | EP | disclosed |
| US-8367667-B2 | Pyrrole derivatives as pharmaceutical agents | EXELIXIS, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20110301128-A1 | Pyrrole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2011-12-08 | — | — | US | disclosed |
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | THE BURNHAM INSTITUTE | 2010-10-14 | — | — | US | disclosed |
| US-7741521-B2 | 4-phenylsulfanyl-phenylamine derivatives used as BH3 Interacting Domain Death Antagonist (BID), for the treatment of neurodegenerative diseases, liver inflammation, multiple sclerosis, heart disease, ischemic injury and for controlling apoptotic cascade | THE BURNHAM INSTITUTE (US) | 2010-06-22 | — | — | US | disclosed |
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1844020-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS | Exelixis, Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | THE BURNHAM INSTITUTE (US) | 2007-08-09 | — | — | US | disclosed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006076202-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTORS LIGANDS | EXELIXIS, INC. (US) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | disclosed |
| US-20040002521-A1 | Cyclopropanecarboxylic acid amide compound and pharmaceutical use thereof | AJINOMOTO CO. INC | 2004-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301128-A1 | Pyrrole Derivatives As Pharmaceutical Agents | PRLHR, PTGDR, TACR1 | TSHR 144/4885LMNA 4213/4885GAA 1346/4885 |
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | BID, BAD, TMBIM6 | TSHR 4415/4885LMNA 2426/4885GAA 3484/4885 |
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | PRLHR, PTGDR, TACR1 | TSHR 144/4885LMNA 4213/4885GAA 1346/4885 |
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | BID, BAD, TMBIM6 | TSHR 4452/4885LMNA 2030/4885GAA 2742/4885 |
| US-20040002521-A1 | Cyclopropanecarboxylic acid amide compound and pharmaceutical use thereof | NFKBIA, IKBKB, CHUK | TSHR 4806/4885LMNA 3431/4885GAA 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.