Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386328 | 1.00 | TSHR (0.46) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL22950649 | 1.00 | TSHR (0.46) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL2386329 | 1.00 | TSHR (0.46) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL27470015 | 0.85 | ALDH1A1 (0.43) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL5028021 | 0.83 | ALDH1A1 (0.41) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL4124188 | 0.83 | ALDH1A1 (0.50) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL5861572 | 0.83 | ALDH1A1 (0.50) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL2705958 | 0.83 | ALDH1A1 (0.50) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL22975094 | 0.83 | LMNA (0.47) | TSHRALDH1A1CYP3A4ALOX15ALOX12 | |
| SCHEMBL11334412 | 0.83 | SAE1 (0.45) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244817-A1 | SUBSTITUTED PIPERIDINES AS CK1A DEGRADERS | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |