Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 12/20 | 0.44 |
| ▸ | MARK3 | P27448 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.42 |
| ▸ | BRSK2 | Q8IWQ3 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | PGK1 | P00558 | 2/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27087784 | 1.00 | TBK1 (0.44) | TBK1MARK3CDK2IKBKEBRSK2 | |
| SCHEMBL3387132 | 0.83 | ALDH1A1 (0.45) | TBK1MARK3CDK2IKBKEBRSK2 | |
| SCHEMBL3387252 | 0.82 | ALDH1A1 (0.48) | TBK1MARK3CDK2IKBKEBRSK2 | |
| SCHEMBL13460158 | 0.80 | TBK1 (0.43) | TBK1MARK3CDK2IKBKEBRSK2 | |
| SCHEMBL3387171 | 0.80 | STK17A (0.42) | TBK1MARK3CDK2IKBKEBRSK2 | |
| SCHEMBL3389341 | 0.79 | TBK1 (0.40) | TBK1MARK3CDK2IKBKEBRSK2 | |
| SCHEMBL22648255 | 0.79 | TBK1 (0.40) | TBK1MARK3CDK2IKBKEBRSK2 | |
| Hydrochloric Acid SCHEMBL3387745 | 0.79 | STK17A (0.42) | TBK1MARK3CDK2IKBKEBRSK2 | |
| SCHEMBL12330931 | 0.79 | PGK1 (0.47) | MKNK1PGK1ACP1STK17AHRH3 | |
| SCHEMBL30800576 | 0.78 | STK17A (0.43) | MKNK1PGK1ACP1STK17AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117545751-A | 2, 4-diaminopyrimidine derivatives as ULK1/2 inhibitors and their use | 生命爱科 | 2024-02-09 | — | — | CN | disclosed |