SCHEMBL30801463

SCHEMBL30801463

COc1ccc2cc(C(CC(=O)O)Nc3ccc(C)cc3)ccc2c1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.51
AKR1C3 P42330 7/20 0.49
AKR1C2 P52895 7/20 0.49
PTGS1 P23219 3/20 0.49
AKR1C1 Q04828 1/20 0.49
PTGS2 P35354 3/20 0.49
CDC42 P60953 1/20 0.49
RAC1 P63000 1/20 0.49
CYP1A2 P05177 1/20 0.49
TSHR P16473 1/20 0.49
SLC22A6 Q4U2R8 1/20 0.49
CTSA P10619 3/20 0.48
FFAR1 O14842 2/20 0.47
RIOK2 Q9BVS4 3/20 0.45
GSK3A P49840 2/20 0.45
MAPK10 P53779 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29157140 1.00 POLB (0.51) POLBAKR1C3AKR1C2PTGS1AKR1C1
SCHEMBL29157113 0.88 TP53 (0.52) POLBTSHRCTSA
SCHEMBL30801465 0.88 TP53 (0.52) POLBTSHRCTSA
SCHEMBL29157156 0.81 FNTA (0.59) POLBTSHRCTSAFFAR1
SCHEMBL14401076 0.78 UTS2R (0.50) CYP1A2
SCHEMBL15782118 0.76 AKR1C3 (0.62) AKR1C3AKR1C2PTGS1AKR1C1PTGS2
SCHEMBL29157145 0.76 SMN1; SMN2 (0.52) CYP1A2TSHRCTSA
SCHEMBL3967988 0.74 ABCB11 (0.67) AKR1C3AKR1C2PTGS1AKR1C1PTGS2
SCHEMBL9696473 0.74 AKR1C3 (0.60) AKR1C3AKR1C2PTGS1AKR1C1PTGS2
SCHEMBL29157107 0.74 UTS2R (0.49) TSHRCTSAFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117550987-A Method for synthesizing beta-amino acid compound based on alkene nitrogen carboxylation reaction 四川大学 2024-02-13 CN disclosed