SCHEMBL30812264

SCHEMBL30812264

COc1cnc(C#CC2CCN(C(=O)OC(C)(C)C)CC2)cn1

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 14/20 0.55
ALDH1A1 P00352 1/20 0.42
JAK2 O60674 1/20 0.42
JAK3 P52333 1/20 0.42
PTK2 Q05397 1/20 0.42
STS P08842 1/20 0.41
MMP13 P45452 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27391936 0.83 ALDH1A1 (0.52) GPR119ALDH1A1STS
SCHEMBL30824737 0.81 GPR119 (0.47) GPR119
SCHEMBL27007401 0.80 GPR119 (0.48) GPR119ALDH1A1
SCHEMBL24233245 0.79 GPR119 (0.50) GPR119
SCHEMBL20137797 0.79 GPR119 (0.67) GPR119ALDH1A1
SCHEMBL16973168 0.77 ALDH1A1 (0.51) GPR119ALDH1A1STS
SCHEMBL27313243 0.76 GPR119 (0.59) GPR119
SCHEMBL1199881 0.76 GPR119 (0.58) GPR119
SCHEMBL31697738 0.74 GPR119 (0.74) GPR119HPGD
SCHEMBL31748110 0.74 GPR119 (0.48) GPR119ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388605-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE HALDA THERAPEUTICS OPCO INC (US) 2025-12-25 US disclosed
WO-2024054956-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE HALDA THERAPEUTICS OPCO, INC. (US) 2024-03-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388605-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE BRD4, BRDT, BICRA GPR119 1499/4885ALDH1A1 2923/4885JAK2 706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.