Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10309173 | 1.00 | THRB (0.51) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL14458703 | 0.86 | KMT2A (0.52) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL20269669 | 0.86 | THRB (0.55) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL30299066 | 0.84 | ALDH1A1 (0.46) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL25353231 | 0.84 | NPY5R (0.56) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL7898674 | 0.84 | NPY5R (0.59) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL6789630 | 0.83 | NPY5R (0.60) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL7897638 | 0.83 | NPY5R (0.60) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL1956562 | 0.83 | NPY5R (0.60) | THRBALDH1A1CA1CA2MMP1 | |
| SCHEMBL18052431 | 0.83 | LMNA (0.62) | THRBALDH1A1CA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555078-B1 | BISARYL HETEROCYCLES AS NRF2 ACTIVATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2024-03-27 | — | — | EP | disclosed |