Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2129704 | 1.00 | LMNA (0.52) | LMNATP53THRBPIK3CBPIK3CA | |
| SCHEMBL2129152 | 0.93 | TP53 (0.46) | LMNATP53THRBPIK3CAKMT2A | |
| SCHEMBL2131362 | 0.93 | MEN1 (0.50) | LMNATP53THRBKMT2ANAPEPLD | |
| SCHEMBL30796423 | 0.93 | TP53 (0.46) | LMNATP53THRBPIK3CAKMT2A | |
| SCHEMBL2128993 | 0.92 | NAPEPLD (0.52) | PIK3CBPIK3CAKMT2ANAPEPLDKDM4E | |
| SCHEMBL2129896 | 0.91 | LMNA (0.44) | LMNATP53THRBPIK3CBPIK3CA | |
| SCHEMBL2129362 | 0.91 | NAPEPLD (0.45) | LMNATP53THRBPIK3CBPIK3CA | |
| SCHEMBL2129978 | 0.91 | ALDH1A1 (0.53) | LMNATHRBNAPEPLDKDM4ETSHR | |
| SCHEMBL2134179 | 0.91 | ALDH1A1 (0.43) | LMNATP53THRBPIK3CBPIK3CA | |
| SCHEMBL30794667 | 0.91 | ALDH1A1 (0.43) | LMNATP53THRBPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054807-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |