Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ARG1 | P05089 | 1/20 | 0.53 |
| ▸ | ARG2 | P78540 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 2/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.50 |
| ▸ | BHMT | Q93088 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 3/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941026 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL10801469 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL10073278 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL11572914 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL3082543 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL11572921 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL8612866 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL9544550 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL20553470 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT | |
| SCHEMBL9028544 | 1.00 | NOS2 (0.57) | NOS2GMNNTP53POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217145-B2 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | THE SCRIPS RESEARCH INSTITUTE (US) | 2012-07-10 | — | — | US | claimed |
| US-20090209000-A1 | Genetically Programmed Expression of Proteins | THE SCRIPPS RESEARCH INSTITUTE | 2009-08-20 | — | — | US | claimed |
| EP-1994165-A2 | GENETICALLY PROGRAMMED EXPRESSION OF PROTEINS CONTAINING THE UNNATURAL AMINO ACID PHENYLSELENOCYSTEINE | The Scripps Research Institute (US) | 2008-11-26 | — | — | EP | claimed |
| US-20070238152-A1 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-10-11 | — | — | US | claimed |
| WO-2007109035-A2 | GENETICALLY PROGRAMMED EXPRESSION OF PROTEINS CONTAINING THE UNNATURAL AMINO ACID PHENYLSELENOCYSTEINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-09-27 | — | — | WO | claimed |
| EP-1994165-B1 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | SCRIPPS RESEARCH INST (US) | 2014-11-05 | — | — | EP | disclosed |
| US-8394605-B2 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-03-12 | — | — | US | disclosed |
| US-20120282668-A1 | Genetically Programmed Expression of Proteins Containing the Unnatural Amino Acid Phenylselenocysteine | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-11-08 | — | — | US | disclosed |
| US-8217145-B2 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | THE SCRIPS RESEARCH INSTITUTE (US) | 2012-07-10 | — | — | US | disclosed |
| US-7790847-B2 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-09-07 | — | — | US | disclosed |
| CN-101795702-A | Oligopeptide tyrosinase inhibitor and application thereof | UNIV LELAND STANFORD JUNIOR | 2010-08-04 | — | — | CN | disclosed |
| CN-101795703-A | peptide tyrosinase inhibitors and uses thereof | UNIV LELAND STANFORD JUNIOR | 2010-08-04 | — | — | CN | disclosed |
| US-20090209000-A1 | Genetically Programmed Expression of Proteins | THE SCRIPPS RESEARCH INSTITUTE | 2009-08-20 | — | — | US | disclosed |
| EP-1994165-A2 | GENETICALLY PROGRAMMED EXPRESSION OF PROTEINS CONTAINING THE UNNATURAL AMINO ACID PHENYLSELENOCYSTEINE | The Scripps Research Institute (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20070238152-A1 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-10-11 | — | — | US | disclosed |
| WO-2007109035-A2 | GENETICALLY PROGRAMMED EXPRESSION OF PROTEINS CONTAINING THE UNNATURAL AMINO ACID PHENYLSELENOCYSTEINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238152-A1 | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine | NPEPPS, AARS1, NSUN3 | NOS2 3226/4885GMNN 1189/4885TP53 3905/4885 |
| US-20090209000-A1 | Genetically Programmed Expression of Proteins | AARS1, COASY, NPEPPS | NOS2 3345/4885GMNN 1396/4885TP53 3931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.