Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27261502 | 1.00 | MAPT (0.49) | MAPTHTR3AGAAKMT2AMEN1 | |
| SCHEMBL24422281 | 0.81 | MAPT (0.38) | MAPTHTR3AGAAKMT2AMEN1 | |
| SCHEMBL82236 | 0.79 | MAPT (0.50) | MAPTHTR3AGAAKMT2AMEN1 | |
| SCHEMBL5647111 | 0.79 | CHRNB2 (0.40) | MAPTFYN | |
| SCHEMBL30786198 | 0.78 | CHRNB2 (0.64) | MAPTHTR3AGAAKMT2AMEN1 | |
| SCHEMBL5199765 | 0.78 | CHRNB2 (0.64) | MAPTHTR3AGAAKMT2AMEN1 | |
| SCHEMBL20037501 | 0.78 | MAPT (0.49) | MAPTHTR3AGAAKMT2AMEN1 | |
| SCHEMBL22411598 | 0.78 | CHRNB2 (0.64) | HTR3AKDM4ESIRT6 | |
| SCHEMBL29664444 | 0.78 | MAPT (0.58) | MAPTHTR3AGAAKMT2AMEN1 | |
| SCHEMBL521324 | 0.78 | MAPT (0.58) | MAPTHTR3AGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4590396-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | Astrazeneca AB (SE) | 2025-07-30 | — | — | EP | disclosed |
| WO-2024062089-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-03-28 | — | — | WO | disclosed |