Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27252315 | 1.00 | TNF (0.52) | TNFPIK3CAGRM4SRCKCNQ3 | |
| SCHEMBL27252312 | 0.77 | TNF (0.48) | TNFPIK3CAGRM4SRCKCNQ3 | |
| SCHEMBL12727110 | 0.77 | RAB9A (0.47) | RAB9AAHRSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL27252314 | 0.76 | TNF (0.50) | TNFPIK3CAGRM4SRCKCNQ3 | |
| SCHEMBL30827602 | 0.76 | TNF (0.47) | TNFPIK3CARAB9AKMT2ANPC1 | |
| SCHEMBL29310766 | 0.76 | TNF (0.47) | TNFPIK3CARAB9AKMT2ANPC1 | |
| SCHEMBL23927057 | 0.75 | PIK3CA (0.57) | TNFPIK3CAGRM4KCNQ3KCNQ2 | |
| SCHEMBL30079596 | 0.75 | PIK3CA (0.57) | TNFPIK3CAGRM4KCNQ3KCNQ2 | |
| SCHEMBL1600224 | 0.74 | MAPT (0.43) | RAB9ANR1I2AHRSMN1; SMN2KMT2A | |
| SCHEMBL13506395 | 0.74 | CYP1A2 (0.49) | RAB9AKMT2ABCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4590397-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | Astrazeneca AB (SE) | 2025-07-30 | — | — | EP | disclosed |
| WO-2024062090-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-03-28 | — | — | WO | disclosed |