Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.49 |
| ▸ | HTR1A | P08908 | 14/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8260377 | 0.82 | KCNH2 (0.39) | DRD2HTR1ABACE1 | |
| SCHEMBL24793957 | 0.81 | KDM4E (0.48) | PARP1 | |
| SCHEMBL29709684 | 0.81 | KDM4E (0.48) | PARP1 | |
| SCHEMBL30082682 | 0.80 | PARP1 (0.40) | PARP1 | |
| SCHEMBL24792909 | 0.80 | PARP1 (0.40) | PARP1 | |
| SCHEMBL31152736 | 0.79 | DRD2 (0.52) | DRD2HTR1APARP1BACE1 | |
| Pardoprunox SCHEMBL29358670 | 0.79 | DRD2 (0.58) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| SCHEMBL8260370 | 0.78 | HTR1A (0.51) | DRD2HTR1ABACE1 | |
| Pardoprunox SCHEMBL1584476 | 0.77 | DRD2 (0.57) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| Pardoprunox SCHEMBL30730668 | 0.77 | DRD2 (0.57) | DRD2HTR1AHTR2AMCHR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |