Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30830608 | 0.91 | MCL1 (0.47) | MCL1BAK1ESR2L3MBTL1ALDH1A1 | |
| SCHEMBL19586153 | 0.86 | L3MBTL1 (0.48) | MCL1BAK1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL31134525 | 0.86 | L3MBTL1 (0.43) | MCL1BAK1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL30830765 | 0.83 | PTGER1 (0.43) | MCL1BAK1L3MBTL1MAPTGRM5 | |
| SCHEMBL25504166 | 0.81 | MCL1 (0.43) | MCL1BAK1ESR2L3MBTL1MAPT | |
| SCHEMBL24207230 | 0.81 | LMNA (0.47) | L3MBTL1MAPTGRM5LMNACYP1A2 | |
| SCHEMBL31390651 | 0.81 | LMNA (0.44) | MCL1BAK1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL30475462 | 0.80 | SQOR (0.44) | MCL1BAK1L3MBTL1MAPTGRM5 | |
| SCHEMBL25035127 | 0.80 | SQOR (0.44) | MCL1BAK1L3MBTL1MAPTGRM5 | |
| SCHEMBL31444197 | 0.80 | ESR2 (0.47) | MCL1BAK1ESR2GRM5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |