Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30840002 | 0.89 | KCNH2 (0.51) | DRD2HTR2AHTR2CKCNH2HTR2B | |
| SCHEMBL30840016 | 0.82 | HTR2A (0.51) | DRD2HTR2AHTR2CKCNH2CACNA1I | |
| SCHEMBL8222029 | 0.81 | CKS1B (0.53) | DRD2KDM4EPKMCKS1BSKP1 | |
| SCHEMBL29208006 | 0.81 | HTR2A (0.54) | DRD2HTR2AHTR2CKCNH2HTR2B | |
| Hydrochloric Acid SCHEMBL29207967 | 0.80 | HTR2A (0.53) | DRD2HTR2AHTR2CKCNH2HTR2B | |
| SCHEMBL30831997 | 0.79 | HTR2A (0.48) | DRD2HTR2AHTR2CKCNH2HTR2B | |
| SCHEMBL30839998 | 0.79 | HTR2A (0.46) | DRD2HTR2AHTR2CKCNH2HTR2B | |
| Hydrochloric Acid SCHEMBL29208110 | 0.79 | HTR2A (0.52) | DRD2HTR2AHTR2CKCNH2HTR2B | |
| SCHEMBL7137625 | 0.79 | ALDH1A1 (0.57) | DRD2HTR2AHTR2CPKM | |
| SCHEMBL29280915 | 0.78 | HTR2A (0.61) | HTR2AHTR2CKCNH2SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964547-A | Urea compound and application thereof as Sigma2 and 5HT2A dual-target inhibitor | 瀚远医药有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2024067302-A1 | AMIDE COMPOUND AND USE THEREOF IN PREPARATION OF INHIBITOR OF SIGMA2 AND 5HT2A | 瀚远医药有限公司 | 2024-04-04 | — | — | WO | disclosed |
| WO-2024067304-A1 | COMPOUND WITH INHIBITORY ACTIVITY AGAINST SIGMA2 AND 5HT2A AND USE | 瀚远医药有限公司 | 2024-04-04 | — | — | WO | disclosed |