Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of 2-Picolinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435396 | 0.84 | KDM4E (0.42) | ALDH1A1L3MBTL1P4HTMKDM4EGAA | |
| SCHEMBL28575256 | 0.83 | KDM4E (0.41) | ALDH1A1L3MBTL1P4HTMKDM4EGAA | |
| Hydrochloric Acid SCHEMBL38657196 | 0.83 | KDM4E (0.41) | ALDH1A1L3MBTL1P4HTMKDM4EGAA | |
| SCHEMBL27590663 | 0.81 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| SCHEMBL29834235 | 0.78 | KDM4E (0.36) | KMT2AALDH1A1L3MBTL1P4HTMKDM4E | |
| SCHEMBL28115999 | 0.75 | KDM4E (0.40) | KMT2AMEN1ALDH1A1L3MBTL1P4HTM | |
| SCHEMBL28452296 | 0.74 | KDM4E (0.39) | ALDH1A1L3MBTL1P4HTMKDM4EGAA | |
| SCHEMBL2291421 | 0.71 | KDM4E (0.42) | KMT2AMEN1ALDH1A1L3MBTL1P4HTM | |
| 2-Picolinic Acid SCHEMBL27536282 | 0.71 | ALDH1A1 (0.63) | KMT2AALDH1A1L3MBTL1P4HTMKDM4E | |
| 2-Picolinic Acid SCHEMBL11378795 | 0.71 | CES2 (0.67) | KMT2AALDH1A1L3MBTL1P4HTMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11905547-B2 | Reagents for electrochemical test strips | AGAMATRIX, INC. (US) | 2024-02-20 | — | — | US | disclosed |