Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDE | P14735 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL21931373 | 1.00 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| SCHEMBL29601544 | 0.92 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| SCHEMBL28054466 | 0.92 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| Dimethylamine SCHEMBL28372138 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| Vonoprazan SCHEMBL194396 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| Vonoprazan SCHEMBL29407867 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| Vonoprazan SCHEMBL31647237 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| Vonoprazan SCHEMBL29379818 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| Fumaric Acid SCHEMBL31647335 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 | |
| Vonoprazan SCHEMBL194394 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118108705-A | Preparation method of voronoi fumarate | 浙江工业大学 | 2024-05-31 | — | — | CN | disclosed |
| CN-108148044-B | Amide compound and method for preparing Vonoprazan fumarate from same | 上海医药工业研究院 | 2024-05-14 | — | — | CN | disclosed |
| CN-113149883-B | Process for preparing pyrrole compounds | 武田药品工业株式会社 | 2024-04-02 | — | — | CN | disclosed |