Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 5/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28274864 | 0.74 | CYP11B1 (0.71) | CYP11B1CYP11B2CYP19A1NCOA3LMNA | |
| SCHEMBL30833265 | 0.73 | CYP11B1 (0.55) | CYP11B1CYP11B2CYP19A1NCOA3MAOA | |
| SCHEMBL2071832 | 0.73 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1NCOA3LMNA | |
| SCHEMBL2532397 | 0.72 | LMNA (0.78) | CYP11B1CYP11B2CYP19A1LMNAMAPT | |
| SCHEMBL7592382 | 0.71 | NOTUM (0.46) | LMNAMAPTNOTUMMEN1KMT2A | |
| SCHEMBL4499181 | 0.71 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1NCOA3LMNA | |
| SCHEMBL12117429 | 0.70 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1NCOA3LMNA | |
| Hydrochloric Acid SCHEMBL28701756 | 0.70 | LMNA (0.75) | CYP11B1CYP11B2CYP19A1LMNAMAPT | |
| SCHEMBL13045131 | 0.70 | CYP19A1 (1.00) | CYP11B1CYP11B2CYP19A1NCOA3LMNA | |
| SCHEMBL15978818 | 0.70 | CYP11B1 (0.65) | CYP11B1CYP11B2CYP19A1NCOA3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |