Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 1.00 |
| ▸ | CYP11B2 | P19099 | 4/20 | 1.00 |
| ▸ | MAOA | P21397 | 6/20 | 0.67 |
| ▸ | MAOB | P27338 | 6/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285074 | 0.84 | CYP11B1 (0.73) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| SCHEMBL6389607 | 0.83 | CYP11B1 (0.71) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| Bromide SCHEMBL28346058 | 0.83 | CYP11B1 (0.71) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| Hydrochloric Acid SCHEMBL28300604 | 0.83 | CYP11B1 (0.71) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| SCHEMBL1903836 | 0.81 | MAOA (1.00) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| SCHEMBL14483736 | 0.81 | CYP11B1 (0.68) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| SCHEMBL31138008 | 0.81 | CYP11B1 (0.68) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| Hydrochloric Acid SCHEMBL1900894 | 0.80 | MAOA (0.98) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| SCHEMBL2071832 | 0.80 | CYP11B1 (1.00) | CYP11B1CYP11B2MAOAMAOBCYP19A1 | |
| SCHEMBL1827414 | 0.79 | MAOA (0.65) | CYP11B1CYP11B2MAOAMAOBCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | claimed |
| EP-1853261-B1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | UNIV SAARLAND (DE) | 2017-01-11 | — | — | EP | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | CYP11B1, HSD11B1, HSD17B1 | CYP11B1 1/4885CYP11B2 5/4885MAOA 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.