Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26536664 | 0.81 | ALDH1A1 (0.70) | ALDH1A1LMNAPOLBGAATSHR | |
| SCHEMBL4635552 | 0.79 | KDM4E (0.56) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL30595144 | 0.78 | KMT2A (0.57) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL2070900 | 0.78 | KMT2A (0.57) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL4636274 | 0.76 | KDM4E (0.54) | ALDH1A1NPC1RAB9ALMNAPOLB | |
| SCHEMBL17942299 | 0.75 | NAMPT (0.53) | MMP2MMP9KMT2AMMP14MMP3 | |
| SCHEMBL28293656 | 0.75 | MAPT (0.51) | MMP2MMP9MEN1KMT2AMMP14 | |
| SCHEMBL4174306 | 0.75 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9ALMNAGAA | |
| SCHEMBL1018493 | 0.74 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL1018436 | 0.72 | HSD17B10 (0.62) | KMT2AALDH1A1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118164961-A | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-111393414-B | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-05-07 | — | — | CN | disclosed |