Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833419 | 0.86 | RIPK1 (0.47) | NR1H2NR1H3GPR119RIPK1MEN1 | |
| SCHEMBL30833386 | 0.80 | RIPK1 (0.45) | NR1H2NR1H3GPR119RIPK1MEN1 | |
| SCHEMBL30833425 | 0.80 | RIPK1 (0.45) | NR1H2NR1H3GPR119RIPK1MEN1 | |
| SCHEMBL17942390 | 0.78 | CYP3A4 (0.54) | GPR119MEN1KMT2ASTSNR1I2 | |
| SCHEMBL3892760 | 0.76 | RIPK1 (0.43) | NR1H2NR1H3GPR119RIPK1 | |
| SCHEMBL17948857 | 0.74 | GPR119 (0.52) | GPR119MEN1KMT2ASTSNR1I2 | |
| SCHEMBL29530176 | 0.74 | GPR119 (0.52) | GPR119MEN1KMT2ASTSNR1I2 | |
| SCHEMBL17942320 | 0.74 | GPR119 (0.52) | GPR119MEN1KMT2ASTSNR1I2 | |
| SCHEMBL29530166 | 0.74 | GPR119 (0.52) | GPR119MEN1KMT2ASTSNR1I2 | |
| SCHEMBL431783 | 0.74 | RIPK1 (0.52) | NR1H2NR1H3GPR119RIPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118164961-A | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-111393414-B | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-05-07 | — | — | CN | disclosed |