Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833786 | 0.85 | EGFR (0.48) | IGF1RMAPK8CDK1PTK2CDK2 | |
| SCHEMBL30833774 | 0.83 | IGF1R (0.43) | IGF1RMAPK8CDK1PTK2CDK2 | |
| SCHEMBL30833734 | 0.82 | ALK (0.49) | IGF1RMAPK8CDK1PTK2CDK2 | |
| SCHEMBL30833660 | 0.82 | ALK (0.43) | IGF1RMAPK8CDK1PTK2CDK2 | |
| SCHEMBL30833764 | 0.82 | IGF1R (0.45) | IGF1RMAPK8CDK1PTK2CDK2 | |
| SCHEMBL30833715 | 0.79 | SYK (0.46) | IGF1RMAPK8CDK1PTK2CDK2 | |
| SCHEMBL30833657 | 0.77 | ZAP70 (0.43) | IGF1RMAPK8CDK1PTK2CDK2 | |
| SCHEMBL30833668 | 0.76 | EGFR (0.52) | ALKJAK2FGFR1SRCFLT3 | |
| SCHEMBL30833776 | 0.75 | ALK (0.48) | PTK2ALKMETFLT3SYK | |
| SCHEMBL30833796 | 0.73 | IGF1R (0.46) | IGF1RMAPK8CDK1CDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |