Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | IGF1R | P08069 | 5/20 | 0.44 |
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833742 | 0.85 | IGF1R (0.43) | EGFRMAPK8SYKIGF1RCDK1 | |
| SCHEMBL30833774 | 0.85 | IGF1R (0.43) | MAPK8SYKIGF1RCDK1CDK2 | |
| SCHEMBL30833734 | 0.84 | ALK (0.49) | EGFRMAPK8SYKIGF1RCDK1 | |
| SCHEMBL30833779 | 0.83 | EGFR (0.48) | EGFRMAPK8SYKIGF1RCDK1 | |
| SCHEMBL30833668 | 0.83 | EGFR (0.52) | EGFRALKJAK2FGFR1SRC | |
| SCHEMBL30833660 | 0.82 | ALK (0.43) | EGFRMAPK8SYKIGF1RCDK1 | |
| SCHEMBL29190693 | 0.81 | GLO1 (0.54) | EGFRMAPK8IGF1RCDK1CDK2 | |
| SCHEMBL30833764 | 0.79 | IGF1R (0.45) | EGFRMAPK8SYKIGF1RCDK1 | |
| SCHEMBL30833715 | 0.78 | SYK (0.46) | MAPK8SYKIGF1RCDK1CDK2 | |
| SCHEMBL30833796 | 0.76 | IGF1R (0.46) | EGFRMAPK8IGF1RCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |