Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 20/20 | 0.68 |
| ▸ | HCRTR2 | O43614 | 20/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3093210 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2 | |
| SCHEMBL3081804 | 0.84 | HCRTR2 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL6924756 | 0.81 | HCRTR2 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL12337043 | 0.78 | HCRTR1 (0.63) | HCRTR1HCRTR2 | |
| SCHEMBL4308253 | 0.76 | HCRTR2 (0.73) | HCRTR1HCRTR2 | |
| SCHEMBL12337680 | 0.74 | HCRTR1 (0.62) | HCRTR1HCRTR2 | |
| SCHEMBL6899415 | 0.74 | HCRTR2 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL1671158 | 0.70 | HCRTR1 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL4306752 | 0.69 | HCRTR2 (0.88) | HCRTR1HCRTR2 | |
| SCHEMBL4321503 | 0.69 | HCRTR2 (0.88) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263586-B2 | OXO bridged diazepan orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2012-09-11 | — | — | US | claimed |
| US-20100227848-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-09-09 | — | — | US | claimed |
| EP-2150114-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2010-02-10 | — | — | EP | claimed |
| WO-2008143856-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-11-27 | — | — | WO | claimed |
| US-10894042-B2 | Methods and pharmaceutical compositions for the treatment of cancer | Inserm (Institut National de la Santa et de la Recherche Medicale) (FR) | 2021-01-19 | — | — | US | disclosed |
| US-20190151304-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATORY | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-05-23 | — | — | US | disclosed |
| US-20190083508-A1 | USE OF OX1R ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-03-21 | — | — | US | disclosed |
| US-8263586-B2 | OXO bridged diazepan orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263586-B2 | OXO bridged diazepan orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2012-09-11 | — | — | US | disclosed |
| US-20100227848-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-09-09 | — | — | US | disclosed |
| US-20100227848-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-09-09 | — | — | US | disclosed |
| WO-2008143856-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151304-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATORY | HCRTR1, HCRTR2, OXTR | HCRTR1 1/4885HCRTR2 2/4885CYP3A4 3942/4885 |
| US-10894042-B2 | Methods and pharmaceutical compositions for the treatment of cancer | OXTR, OGFR, OXGR1 | HCRTR1 18/4885HCRTR2 14/4885CYP3A4 2021/4885 |
| US-20100227848-A1 | OXO BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | HCRTR1 2/4885HCRTR2 1/4885CYP3A4 2926/4885 |
| US-20190083508-A1 | USE OF OX1R ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES | GPR180, OXGR1, MLNR | HCRTR1 22/4885HCRTR2 17/4885CYP3A4 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.