Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30834678 | 0.82 | SLC6A3 (0.43) | SLC6A3SLC6A2SLC6A4ABCC1LMNA | |
| SCHEMBL1700317 | 0.82 | SLC6A3 (0.45) | SLC6A3SLC6A2SLC6A4ABCC1LMNA | |
| SCHEMBL1956675 | 0.79 | LMNA (0.54) | SLC6A3SLC6A2SLC6A4ABCC1LMNA | |
| SCHEMBL22325105 | 0.77 | BCL2L1 (0.63) | MAPTTSHRSMN1; SMN2GAA | |
| SCHEMBL25711711 | 0.77 | BCL2L1 (0.63) | MAPTTSHRSMN1; SMN2GAA | |
| SCHEMBL1955746 | 0.76 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL1743636 | 0.76 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4ALPLCHRM5 | |
| SCHEMBL21332404 | 0.75 | SLC6A3 (0.72) | SLC6A3SLC6A2SLC6A4CHRM5CHRM1 | |
| SCHEMBL30834660 | 0.75 | SLC6A3 (0.41) | SLC6A3SLC6A2SLC6A4ABCC1LMNA | |
| SCHEMBL15921083 | 0.72 | SLC6A3 (0.50) | SLC6A3SLC6A2SLC6A4MAPTCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886881-A | Chimeric compound for targeted degradation of BCL-2 protein, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-04-16 | — | — | CN | disclosed |