Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22325249 | 0.92 | SLC6A3 (0.50) | SLC6A3SLC6A2LMNASLC6A4ALDH1A1 | |
| SCHEMBL22335527 | 0.85 | SLC6A2 (0.40) | SLC6A3SLC6A2SLC6A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL30834678 | 0.82 | SLC6A3 (0.43) | SLC6A3SLC6A2TARBP2LMNAMAPT | |
| SCHEMBL22325101 | 0.80 | BCL2L1 (0.56) | MAPTGAA | |
| SCHEMBL30857610 | 0.80 | BCL2L1 (0.56) | MAPTGAA | |
| SCHEMBL22325047 | 0.79 | BCL2L1 (0.34) | SLC6A3SLC6A2ACHE | |
| SCHEMBL30857548 | 0.79 | BCL2L1 (0.34) | SLC6A3SLC6A2ACHE | |
| SCHEMBL30834667 | 0.76 | SMN1; SMN2 (0.43) | LMNAMAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1700317 | 0.75 | SLC6A3 (0.45) | SLC6A3SLC6A2TARBP2LMNAMAPT | |
| SCHEMBL30834666 | 0.75 | SLC6A3 (0.42) | SLC6A3SLC6A2TARBP2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886881-A | Chimeric compound for targeted degradation of BCL-2 protein, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-04-16 | — | — | CN | disclosed |