SCHEMBL30834751

SCHEMBL30834751

Clc1ccc(-c2cccc(I)c2)cc1Br

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 2/20 0.38
METAP2 P50579 1/20 0.36
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
APP P05067 2/20 0.34
ESR2 Q92731 2/20 0.33
CYP1B1 Q16678 1/20 0.33
ALOX5 P09917 1/20 0.32
PTGES2 Q9H7Z7 1/20 0.32
GALR1 P47211 1/20 0.32
TAAR1 Q96RJ0 1/20 0.32
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
APEX1 P27695 1/20 0.31
CNR1 P21554 1/20 0.30
CYP3A4 P08684 3/20 0.30
CYP2C9 P11712 1/20 0.30
HSD17B1 P14061 1/20 0.30
HSD17B2 P37059 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL457778 0.79 ESR2 (0.52) AHRESR2CYP1B1ALOX5CRHBP
SCHEMBL29921215 0.79 ESR2 (0.52) AHRESR2CYP1B1ALOX5CRHBP
SCHEMBL29652220 0.77
SCHEMBL14893542 0.77
SCHEMBL22652789 0.76 HSD17B1 (0.48) METAP2CHRNB4CHRNA3APPESR2
SCHEMBL6561405 0.76 METAP2 (0.50) METAP2CHRNB4CHRNA3APPCYP1B1
SCHEMBL2162915 0.75 ALDH1A1 (0.54) METAP2CHRNB4CHRNA3GALR1CYP3A4
SCHEMBL24730557 0.75 CYP1A2 (0.54) AHRMETAP2CHRNB4CHRNA3ALOX5
SCHEMBL30834750 0.74 SMN1; SMN2 (0.37) AHRMETAP2CHRNB4CHRNA3APP
SCHEMBL16533468 0.73 ADORA2A (0.42) AHRESR2HSD17B1HSD17B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112047930-B Compound and application thereof, and organic electroluminescent device comprising compound 北京鼎材科技有限公司 2024-03-12 CN disclosed