Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.53 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | RXRB | P28702 | 3/20 | 0.33 |
| ▸ | RXRG | P48443 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624105 | 0.96 | NOS3 (0.59) | NOS3NOS1NOS2BCL2L1BAD | |
| SCHEMBL13021590 | 0.74 | NOS3 (0.53) | NOS3NOS1NOS2BCL2L1BAD | |
| SCHEMBL16658453 | 0.74 | NOS2 (0.92) | NOS3NOS1NOS2BCL2L1BAD | |
| SCHEMBL19310981 | 0.74 | NOS3 (0.53) | NOS3NOS1NOS2BCL2L1BAD | |
| SCHEMBL19444169 | 0.74 | NOS3 (0.48) | NOS3NOS1NOS2BCL2L1BAD | |
| Hydrochloric Acid SCHEMBL16650985 | 0.72 | NOS2 (0.88) | NOS3NOS1NOS2BCL2L1BAD | |
| SCHEMBL30474281 | 0.72 | PNMT (0.46) | — | |
| SCHEMBL29848830 | 0.72 | NOS3 (0.47) | NOS3NOS1NOS2LNPEPRXRA | |
| SCHEMBL16651284 | 0.72 | NOS3 (0.47) | NOS3NOS1NOS2LNPEPRXRA | |
| SCHEMBL2624104 | 0.70 | NOS3 (0.59) | NOS3NOS1NOS2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024069448-A1 | SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-04-04 | — | — | WO | disclosed |