Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.30 |
| ▸ | THRA | P10827 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27283125 | 1.00 | TRPA1 (0.32) | TRPA1RHEBTHRATHRB | |
| SCHEMBL30805103 | 0.87 | TRPA1 (0.33) | TRPA1RHEB | |
| SCHEMBL27265131 | 0.87 | TRPA1 (0.33) | TRPA1RHEB | |
| SCHEMBL30805006 | 0.87 | — | — | |
| SCHEMBL27276374 | 0.87 | — | — | |
| Iodide SCHEMBL30750030 | 0.86 | RHEB (0.30) | TRPA1RHEB | |
| SCHEMBL30217128 | 0.86 | TRPA1 (0.34) | TRPA1RHEBTHRATHRB | |
| SCHEMBL30750124 | 0.86 | F10 (0.32) | TRPA1RHEB | |
| Iodide SCHEMBL30805022 | 0.86 | — | — | |
| SCHEMBL30840100 | 0.84 | PRKAB2 (0.38) | TRPA1RHEBTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583972-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | Sionna Therapeutics Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054840-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SIONNA THERAPEUTICS (US) | 2024-03-14 | — | — | WO | disclosed |