Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13259310 | 0.82 | ESR1 (0.39) | ESR1ESR2ALDH1A1MAPTBRD4 | |
| SCHEMBL3633908 | 0.77 | BRD4 (0.46) | MEN1ALDH1A1MAPTKMT2ABRD4 | |
| SCHEMBL16836002 | 0.77 | MEN1 (0.36) | ESR1ESR2MEN1ALDH1A1MAPT | |
| SCHEMBL27284536 | 0.75 | ESR1 (0.35) | ESR1ESR2MEN1ALDH1A1MAPT | |
| SCHEMBL30840562 | 0.75 | ESR1 (0.35) | ESR1ESR2MEN1ALDH1A1MAPT | |
| SCHEMBL13259212 | 0.75 | OPRM1 (0.43) | ESR1ESR2MEN1ALDH1A1MAPT | |
| SCHEMBL11881166 | 0.74 | ESR1 (0.38) | ESR1ESR2BRD4OPRM1SLC22A1 | |
| SCHEMBL11563271 | 0.74 | ALDH1A1 (0.42) | MEN1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL11527873 | 0.74 | MAPK1 (0.40) | MEN1ALDH1A1KMT2ABRD4AKR1C3 | |
| SCHEMBL4520334 | 0.73 | CXCR5 (0.43) | ESR1ESR2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583972-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | Sionna Therapeutics Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054840-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SIONNA THERAPEUTICS (US) | 2024-03-14 | — | — | WO | disclosed |