Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIR | O00625 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445295 | 0.79 | CA2 (0.44) | ALDH1A1GAAPKMLMNAMAPT | |
| SCHEMBL578328 | 0.79 | ALDH1A1 (0.51) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL30869939 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL578733 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL1219330 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL18428696 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL6267237 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL12595169 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL20958124 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL22945552 | 0.77 | BCHE (0.41) | ALDH1A1GAAPKMLMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583972-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | Sionna Therapeutics Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054840-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SIONNA THERAPEUTICS (US) | 2024-03-14 | — | — | WO | disclosed |