Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7622203 | 0.80 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL27286630 | 0.77 | ALDH1A1 (0.45) | ALDH1A1PREP | |
| Bromide SCHEMBL8563395 | 0.76 | HDAC1 (0.43) | ALDH1A1 | |
| Bromide SCHEMBL8563399 | 0.76 | HDAC1 (0.43) | ALDH1A1 | |
| SCHEMBL6628629 | 0.76 | ALDH1A1 (0.44) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13244922 | 0.76 | ALDH1A1 (0.44) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4701620 | 0.76 | ALDH1A1 (0.44) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7845558 | 0.76 | ALDH1A1 (0.44) | ALDH1A1PREPNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4701828 | 0.74 | ALDH1A1 (0.43) | ALDH1A1PREPSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4700390 | 0.74 | ALDH1A1 (0.43) | ALDH1A1PREPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583972-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | Sionna Therapeutics Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054840-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SIONNA THERAPEUTICS (US) | 2024-03-14 | — | — | WO | disclosed |