Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 14/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30842155 | 0.83 | KIF18A (0.65) | KIF18A | |
| SCHEMBL31001665 | 0.79 | KIF18A (0.53) | KIF18A | |
| SCHEMBL30842179 | 0.74 | KIF18A (0.51) | KIF18A | |
| SCHEMBL22964565 | 0.74 | MEN1 (0.40) | KIF18APOLBNPC1RAB9AKMT2A | |
| SCHEMBL29578579 | 0.74 | MEN1 (0.40) | KIF18APOLBNPC1RAB9AKMT2A | |
| SCHEMBL30842126 | 0.74 | KIF18A (0.51) | KIF18A | |
| SCHEMBL31546239 | 0.72 | KIF18A (0.46) | KIF18A | |
| SCHEMBL30842172 | 0.72 | KIF18A (0.51) | KIF18A | |
| SCHEMBL30600578 | 0.72 | KIF18A (0.41) | KIF18A | |
| SCHEMBL26151303 | 0.72 | KIF18A (0.48) | KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4567032-A1 | KIF18A INHIBITOR COMPOUND, AND PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR AND USE THEREOF | Changchun Genescience Pharmaceutical Co., Ltd. (CN) | 2025-06-11 | — | — | EP | disclosed |
| CN-119731163-A | KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2025-03-28 | — | — | CN | disclosed |
| WO-2024051755-A1 | KIF18A INHIBITOR COMPOUND, AND PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR AND USE THEREOF | 长春金赛药业有限责任公司 | 2024-03-14 | — | — | WO | disclosed |