Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | TSPO | P30536 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20476287 | 1.00 | TLR7 (0.39) | TLR7TLR8NLRP3L3MBTL1TSPO | |
| SCHEMBL26863050 | 0.88 | NLRP3 (0.42) | TLR7TLR8NLRP3L3MBTL1 | |
| SCHEMBL30842239 | 0.87 | TLR7 (0.55) | TLR7TLR8NLRP3 | |
| SCHEMBL20741453 | 0.87 | TLR7 (0.55) | TLR7TLR8NLRP3 | |
| SCHEMBL20741457 | 0.86 | TLR7 (0.36) | TLR7TLR8NLRP3L3MBTL1TSPO | |
| SCHEMBL20741497 | 0.85 | NLRP3 (0.43) | TLR7TLR8NLRP3L3MBTL1TSPO | |
| SCHEMBL30842206 | 0.85 | NLRP3 (0.43) | TLR7TLR8NLRP3L3MBTL1TSPO | |
| SCHEMBL29920814 | 0.81 | TSPO (0.39) | TLR7NLRP3L3MBTL1TSPOMMP1 | |
| SCHEMBL21949797 | 0.81 | TSPO (0.39) | TLR7NLRP3L3MBTL1TSPOMMP1 | |
| SCHEMBL20475956 | 0.77 | TLR7 (0.62) | TLR7TLR8NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325534-B | Substituted imidazoquinolines as NLRP3 modulators | 先天肿瘤免疫公司 | 2024-04-05 | — | — | CN | disclosed |