Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.58 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033300 | 0.88 | EGLN1 (0.50) | TGFBR1EGLN1ABL1LRRK2PIK3CA | |
| SCHEMBL30845768 | 0.88 | TGFBR1 (0.54) | TGFBR1EGLN1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL21033468 | 0.83 | KDM4E (0.56) | TGFBR1EGLN1PIK3CA | |
| SCHEMBL30845775 | 0.80 | TGFBR1 (0.55) | TGFBR1EGLN1ALDH1A3 | |
| SCHEMBL21688725 | 0.79 | TGFBR1 (0.49) | TGFBR1 | |
| SCHEMBL30845786 | 0.79 | EGLN1 (0.63) | TGFBR1EGLN1ALDH1A3 | |
| SCHEMBL30845778 | 0.79 | EGLN1 (0.64) | TGFBR1EGLN1ALDH1A3 | |
| SCHEMBL29908155 | 0.78 | USP30 (0.54) | TGFBR1EGLN1PIK3CG | |
| SCHEMBL30845764 | 0.78 | TGFBR1 (0.50) | TGFBR1EGLN1 | |
| SCHEMBL8065354 | 0.78 | TGFBR1 (0.50) | TGFBR1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |