Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.63 |
| ▸ | ALDH1A3 | P47895 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30845778 | 0.88 | EGLN1 (0.64) | EGLN1ALDH1A3ALDH1A1TGFBR1 | |
| SCHEMBL30977270 | 0.87 | EGLN1 (0.66) | EGLN1ALDH1A3ALDH1A1ALDH1A2SLC2A1 | |
| SCHEMBL3660590 | 0.87 | EGLN1 (0.66) | EGLN1ALDH1A3ALDH1A1ALDH1A2SLC2A1 | |
| SCHEMBL2088007 | 0.83 | EGLN1 (0.61) | EGLN1ALDH1A3ALDH1A1ALDH1A2SLC2A1 | |
| SCHEMBL21033184 | 0.81 | ALDH1A3 (0.60) | EGLN1ALDH1A3ALDH1A1ALDH1A2SLC2A1 | |
| SCHEMBL30845768 | 0.80 | TGFBR1 (0.54) | EGLN1ALDH1A3TGFBR1NR4A2CYP2C9 | |
| SCHEMBL30845797 | 0.80 | TGFBR1 (0.48) | EGLN1TGFBR1NR4A2 | |
| SCHEMBL3366348 | 0.80 | CYP2C9 (0.73) | EGLN1NR4A2CYP2C9 | |
| SCHEMBL22926313 | 0.79 | EGLN1 (0.60) | EGLN1ALDH1A3ALDH1A1ALDH1A2SLC2A1 | |
| SCHEMBL30845755 | 0.79 | MAP3K5 (0.52) | EGLN1TGFBR1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |