Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | KLK7 | P49862 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 6/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HPN | P05981 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30846653 | 0.98 | NPC1 (0.55) | NPC1RAB9AEPHX1KLK7HTR2B | |
| SCHEMBL20852646 | 0.87 | IDO1 (0.50) | KLK7IDO1CYP2C9MAPTRECQL | |
| SCHEMBL20866546 | 0.86 | HTR1E (0.62) | NPC1RAB9AEPHX1MAPTHPN | |
| SCHEMBL22809038 | 0.85 | SMN1; SMN2 (0.57) | NPC1RAB9AEPHX1IDO1CYP2C9 | |
| SCHEMBL5844661 | 0.82 | CTSS (0.50) | NPC1RAB9AEPHX1KLK7HTR2B | |
| SCHEMBL20838723 | 0.81 | IDO1 (0.51) | NPC1RAB9AKLK7IDO1CYP2C9 | |
| SCHEMBL17737122 | 0.81 | IDO1 (0.51) | NPC1RAB9AKLK7IDO1CYP2C9 | |
| SCHEMBL17737121 | 0.81 | IDO1 (0.51) | NPC1RAB9AKLK7IDO1CYP2C9 | |
| SCHEMBL20852663 | 0.81 | IDO1 (0.51) | NPC1RAB9AKLK7IDO1CYP2C9 | |
| SCHEMBL29246374 | 0.78 | NPC1 (0.54) | NPC1RAB9AEPHX1KLK7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116910-A1 | Heterocycles as WIP1 Inhibitors | PMV PHARMACEUTICALS, INC. | 2024-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240116910-A1 | Heterocycles as WIP1 Inhibitors | WAPL, WHR1, G3BP1 | NPC1 4332/4885RAB9A 868/4885EPHX1 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.