Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.31 |
| ▸ | IL1B | P01584 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 4/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847670 | 1.00 | DRD2 (0.36) | DRD2DRD3SCN9AKCNH2HDAC1 | |
| SCHEMBL30847803 | 1.00 | DRD2 (0.36) | DRD2DRD3SCN9AKCNH2HDAC1 | |
| SCHEMBL30847611 | 0.81 | DRD3 (0.40) | DRD2DRD3SCN9AKCNH2HDAC1 | |
| SCHEMBL30847704 | 0.78 | AR (0.36) | DRD2DRD3SCN9AKCNH2 | |
| SCHEMBL30847744 | 0.78 | AR (0.36) | DRD2DRD3SCN9AKCNH2 | |
| SCHEMBL30847677 | 0.76 | DRD2 (0.36) | DRD2DRD3KCNH2HDAC1 | |
| SCHEMBL30847656 | 0.75 | DRD2 (0.34) | DRD2DRD3SCN9AKCNH2 | |
| SCHEMBL30847592 | 0.69 | CMA1 (0.34) | SCN9A | |
| SCHEMBL30847593 | 0.68 | TACR1 (0.33) | IL1B | |
| SCHEMBL3471790 | 0.66 | TP53 (0.56) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |