Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847704 | 1.00 | AR (0.36) | ARDRD2DRD3SCN9AMEN1 | |
| SCHEMBL30847726 | 0.84 | DRD2 (0.38) | ARDRD2DRD3SCN9AMEN1 | |
| SCHEMBL30847685 | 0.80 | MEN1 (0.35) | ARDRD2DRD3SCN9AMEN1 | |
| SCHEMBL29317061 | 0.78 | PPARG (0.41) | ARMEN1ALDH1A1KMT2A | |
| SCHEMBL30847670 | 0.78 | DRD2 (0.36) | DRD2DRD3SCN9AKCNH2 | |
| SCHEMBL30847604 | 0.78 | DRD2 (0.36) | DRD2DRD3SCN9AKCNH2 | |
| SCHEMBL30847803 | 0.78 | DRD2 (0.36) | DRD2DRD3SCN9AKCNH2 | |
| SCHEMBL30847650 | 0.76 | ALOX5 (0.39) | ARMEN1ALDH1A1KMT2ARPS6KB1 | |
| SCHEMBL30847657 | 0.75 | SCN5A (0.43) | SCN9APTPN2PTPN1PTPN6RXRA | |
| SCHEMBL30847795 | 0.73 | CYP1A2 (0.41) | MEN1ALDH1A1KMT2ARPS6KB1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |