Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | POLQ | O75417 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29314388 | 0.83 | POLQ (0.50) | POLQMEN1KMT2A | |
| SCHEMBL30847823 | 0.79 | TACR1 (0.43) | TACR1SLC6A4POLQMEN1KMT2A | |
| SCHEMBL29314384 | 0.75 | POLQ (0.52) | TACR1POLQ | |
| SCHEMBL30847641 | 0.74 | POLQ (0.43) | TACR1POLQMEN1KMT2A | |
| SCHEMBL29314831 | 0.74 | POLQ (0.42) | TACR1SLC6A4POLQ | |
| SCHEMBL29315012 | 0.73 | POLQ (0.41) | TACR1SLC6A4POLQ | |
| SCHEMBL30847644 | 0.70 | POLQ (0.41) | POLQMEN1KMT2A | |
| SCHEMBL30847616 | 0.70 | GPBAR1 (0.36) | TACR1POLQ | |
| SCHEMBL30847689 | 0.70 | LIPE (0.39) | POLQMEN1KMT2AEPHX2 | |
| SCHEMBL30847596 | 0.69 | POLQ (0.50) | POLQMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |