Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RGS12 | O14924 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19204861 | 0.79 | ALDH1A1 (0.39) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL30029189 | 0.78 | DDB1 (0.47) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL24754835 | 0.78 | DDB1 (0.47) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL13106136 | 0.75 | SSTR4 (0.44) | PARP1 | |
| SCHEMBL30848080 | 0.75 | DDB1 (0.45) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL29901540 | 0.72 | GPR3 (0.44) | DDB1CRBNALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL19986782 | 0.72 | GPR3 (0.44) | DDB1CRBNALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL9181361 | 0.70 | SCN9A (0.42) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL30847980 | 0.70 | JAK2 (0.30) | — | |
| SCHEMBL30848071 | 0.67 | DDB1 (0.38) | DDB1CRBNALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |