Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27140925 | 0.88 | JAK2 (0.35) | JAK2BTK | |
| SCHEMBL31583384 | 0.73 | ESR1 (0.38) | JAK2BTK | |
| SCHEMBL27138457 | 0.70 | DDB1 (0.47) | — | |
| SCHEMBL30847906 | 0.70 | DDB1 (0.47) | — | |
| SCHEMBL30848071 | 0.70 | DDB1 (0.38) | — | |
| SCHEMBL13106346 | 0.68 | LMNA (0.43) | JAK2BTK | |
| SCHEMBL31583269 | 0.67 | L3MBTL1 (0.34) | JAK2BTK | |
| SCHEMBL30706223 | 0.67 | LMNA (0.37) | JAK2BTK | |
| SCHEMBL15995385 | 0.67 | DDB1 (0.38) | BTK | |
| SCHEMBL26637934 | 0.67 | LMNA (0.37) | JAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |