Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29318336 | 0.85 | SMO (0.37) | NR1H4P2RX7HSD11B1 | |
| SCHEMBL30892954 | 0.85 | SMO (0.37) | NR1H4P2RX7HSD11B1 | |
| SCHEMBL30892906 | 0.79 | P2RX7 (0.39) | NR1H4P2RX7HSD11B1 | |
| SCHEMBL30849241 | 0.77 | NR1H4 (0.36) | NR1H4NFKB1GAA | |
| SCHEMBL30849221 | 0.76 | P2RX7 (0.39) | NR1H4P2RX7HSD11B1 | |
| SCHEMBL30849233 | 0.74 | SLC6A5 (0.35) | NR1H4P2RX7NPC1RAB9ASLC6A5 | |
| Trifluoroacetic Acid SCHEMBL30892911 | 0.74 | HSD11B1 (0.38) | NR1H4HSD11B1 | |
| SCHEMBL30849257 | 0.71 | TSHR (0.40) | NR1H4NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL30892941 | 0.69 | NR1H4 (0.41) | NR1H4P2RX7HSD11B1 | |
| SCHEMBL30892897 | 0.66 | NR1H4 (0.35) | NR1H4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598908-A1 | HSD17B13 INHIBITORS AND/OR DEGRADERS | Pfizer Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024075051-A1 | HSD17B13 INHIBITORS AND/OR DEGRADERS | PFIZER INC. (US) | 2024-04-11 | — | — | WO | disclosed |