Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30849377 | 1.00 | EPAS1 (0.40) | EPAS1CYP11B1CYP11B2GFRA3RET | |
| SCHEMBL12696395 | 0.78 | EPAS1 (0.34) | EPAS1GFRA3RET | |
| SCHEMBL30849376 | 0.78 | OPRL1 (0.36) | OPRL1 | |
| SCHEMBL30702240 | 0.78 | FNTA (0.33) | GFRA3RET | |
| SCHEMBL24729873 | 0.78 | GFRA3 (0.31) | EPAS1GFRA3RET | |
| SCHEMBL23937987 | 0.78 | DRD2 (0.36) | EPAS1GFRA3RETOPRL1 | |
| SCHEMBL14616897 | 0.78 | FNTA (0.33) | GFRA3RET | |
| SCHEMBL30856753 | 0.78 | FNTA (0.33) | GFRA3RET | |
| SCHEMBL568654 | 0.78 | TRPM5 (0.36) | EPAS1GFRA3RET | |
| SCHEMBL12273044 | 0.74 | CYP11B1 (0.38) | EPAS1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117800949-A | Pyrimidine-containing polycyclic derivative, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-04-02 | — | — | CN | disclosed |