Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.47 |
| ▸ | KRAS | P01116 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3544756 | 0.99 | PTGDR2 (0.46) | PTGDR2KRASBAZ2BHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL3096737 | 0.88 | PTGDR2 (0.58) | PTGDR2KRASHDAC1HDAC6PTGDR | |
| Hydrochloric Acid SCHEMBL3084827 | 0.84 | PTGDR2 (0.56) | PTGDR2KRASBAZ2BSIRT2PTGDR | |
| SCHEMBL16381991 | 0.82 | BAZ2B (0.60) | PTGDR2KRASBAZ2BHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL3084042 | 0.81 | PTGDR2 (0.56) | PTGDR2PTGDR | |
| Hydrochloric Acid SCHEMBL3081708 | 0.81 | BAZ2B (0.59) | PTGDR2KRASBAZ2BHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL3085389 | 0.81 | KRAS (0.60) | PTGDR2KRASBAZ2BHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL3087433 | 0.81 | PTGDR2 (0.58) | PTGDR2KRASBAZ2BHDAC1HDAC6 | |
| SCHEMBL5627158 | 0.79 | KDM4E (0.67) | PTGDR2HDAC1HDAC6PTGDRKDM4E | |
| Hydrochloric Acid SCHEMBL3081497 | 0.79 | HSD17B10 (0.43) | PTGDR2KRASBAZ2BHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234396-A1 | Tetrhydropyridoindole Derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234396-A1 | Tetrhydropyridoindole Derivatives | TPH2, TPH1, HTR5A | PTGDR2 170/4885KRAS 1026/4885BAZ2B 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.