Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257563 | 1.00 | P2RX7 (0.37) | P2RX7IDO1AGXTNR3C2KDM4C | |
| SCHEMBL6002267 | 0.86 | MAPT (0.35) | P2RX7NR3C2KDM4CKDM5AKDM5B | |
| SCHEMBL11116185 | 0.82 | SLC6A4 (0.39) | P2RX7ACHEPTGS1PTGS2 | |
| SCHEMBL7901204 | 0.79 | P2RX7 (0.41) | P2RX7IDO1AGXTNR3C2MMP1 | |
| SCHEMBL28056457 | 0.78 | IDO1 (0.40) | IDO1AGXTCYP1A2SMN1; SMN2 | |
| SCHEMBL14533298 | 0.77 | P2RX7 (0.37) | P2RX7IDO1AGXTNR3C2KDM4C | |
| SCHEMBL13787148 | 0.77 | IDO1 (0.41) | P2RX7IDO1AGXTNR3C2KDM4C | |
| SCHEMBL1371586 | 0.77 | P2RX7 (0.37) | P2RX7IDO1AGXTNR3C2MMP1 | |
| SCHEMBL2476555 | 0.77 | MAPK14 (0.40) | P2RX7IDO1AGXTNR3C2KDM4C | |
| SCHEMBL2475943 | 0.77 | MPO (0.44) | P2RX7IDO1AGXTNR3C2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110770214-B | Heterocyclic P2X7 antagonists | 布雷耶疗法有限公司 | 2024-03-29 | — | — | CN | disclosed |