Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2286658 | 0.91 | P2RX7 (0.38) | MAPTTDP1L3MBTL1P2RX7KDM4E | |
| SCHEMBL30849549 | 0.86 | P2RX7 (0.37) | P2RX7KDM5AKDM4CKDM5BNR3C2 | |
| SCHEMBL4257563 | 0.86 | P2RX7 (0.37) | P2RX7KDM5AKDM4CKDM5BNR3C2 | |
| SCHEMBL957181 | 0.77 | SLC6A4 (0.40) | MAPTTDP1L3MBTL1P2RX7KDM4E | |
| SCHEMBL1096617 | 0.73 | CYP2A6 (0.49) | MAPTTDP1L3MBTL1KDM4ESLC6A4 | |
| SCHEMBL30641468 | 0.73 | MAPT (0.47) | MAPTTDP1L3MBTL1P2RX7KDM4E | |
| SCHEMBL155498 | 0.73 | MAPT (0.47) | MAPTTDP1L3MBTL1P2RX7KDM4E | |
| SCHEMBL1822997 | 0.72 | PYCR1 (0.44) | MAPTTDP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL29700948 | 0.72 | IDO1 (0.48) | MAPTTDP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL548158 | 0.72 | IDO1 (0.48) | MAPTTDP1L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636221-A2 | NEW AZETIDINE COMPOUNDS | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110344-A2 | NEW AZETIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | WO | disclosed |