Acefylline

Acefylline

SCHEMBL1173152

C[SiH2]O.Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 9/20 0.89
SMN1; SMN2 Q16637 3/20 0.66
LMNA P02545 2/20 0.62
MEN1 O00255 1/20 0.62
KMT2A Q03164 1/20 0.62
MAPT P10636 1/20 0.58
MAPK1 P28482 2/20 0.57
RXFP1 Q9HBX9 2/20 0.57
ALDH1A1 P00352 1/20 0.57
PDE4A P27815 1/20 0.56
PDE4B Q07343 1/20 0.56
PDE4C Q08493 1/20 0.56
PDE4D Q08499 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acefylline SCHEMBL18191994 0.94 ADORA2B (1.00) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL308514 0.94 ADORA2B (1.00) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL8402147 0.93 ADORA2B (0.97) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL356114 0.87 ADORA2B (0.85) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL5493561 0.87 ADORA2B (0.85) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL17204841 0.86 ADORA2B (0.84) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
SCHEMBL17163939 0.83 ADORA2B (0.78) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
SCHEMBL11531219 0.83 ADORA2B (0.78) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
SCHEMBL10178114 0.83 ADORA2B (0.73) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL10178116 0.83 PDE4A (0.81) ADORA2BPDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 191 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2821056-A1 Cosmetic composition, formulation gel-cream and its use EMS S.A. (BR) 2015-01-07 EP claimed
US-20150005255-A1 COSMETIC COMPOSITION, FORMULATION IN GEL-CREAM AND ITS USE EMS S.A. (BR) 2015-01-01 US claimed
US-20240237643-A1 COMPOSITIONS WITH VIRUCIDAL AND/OR ANTIVIRAL ACTIVITY SYMRISE AG (DE) 2024-07-18 US disclosed
US-20240216248-A1 MICROBIAL GLYCOLIPIDS ANALYTICON DISCOVERY GMBH (DE) 2024-07-04 US disclosed
EP-4387587-A1 COMPOSITIONS Symrise AG (DE) 2024-06-26 EP disclosed
US-20240173227-A1 A FRAGRANCE MIXTURE CONTAINING ISOCITRONELLOL SYMRISE AG (DE) 2024-05-30 US disclosed
WO-2024110515-A1 AN ACTIVE COMPOSITION COMPRISING RETINOL SYMRISE AG (DE) 2024-05-30 WO disclosed
WO-2024110023-A1 AN ACTIVE COMPOSITION COMPRISING RETINOL SYMRISE AG (DE) 2024-05-30 WO disclosed
WO-2024104625-A1 A BLEND OF EMOLLIENTS SYMRISE AG (DE) 2024-05-23 WO disclosed
WO-2024104546-A1 A BLEND OF EMOLLIENTS SYMRISE AG (DE) 2024-05-23 WO disclosed
US-20240122816-A1 ARTICLES FOR INDIRECT TRANSFER OF COSMETIC ACTIVES TO SKIN SYMRISE AG (DE) 2024-04-18 US disclosed
US-20060205904-A1 Oil gels of controlled distribution block copolymers and ester oils UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT 2006-09-14 US disclosed
US-20060205849-A1 Oil gels of controlled distribution block copolymers and ester oils KRATON POLYMERS U.S. LLC 2006-09-14 US disclosed
EP-1141111-B1 GEL COMPOSITIONS PENRECO (US) 2005-08-03 EP disclosed
US-6881776-B2 Gel compositions PENRECO (US) 2005-04-19 US disclosed
US-20050004274-A1 Gel compositions HEALY LIN LU (US) 2005-01-06 US disclosed
EP-1256336-A2 Two-phase gel composition Penreco (US) 2002-11-13 EP disclosed
US-20020055562-A1 Gel compositions WILMINGTON TRUST, NATIONAL ASSOCIATION 2002-05-09 US disclosed
EP-1141111-A1 GEL COMPOSITIONS Penreco (US) 2001-10-10 EP disclosed
WO-2000026285-A1 GEL COMPOSITIONS PENRECO (US) 2000-05-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216248-A1 MICROBIAL GLYCOLIPIDS UGCG, SGMS1, GPR119 ADORA2B 3644/4885SMN1; SMN2 4097/4885LMNA 4411/4885
US-20240122816-A1 ARTICLES FOR INDIRECT TRANSFER OF COSMETIC ACTIVES TO SKIN CUTA, POLR1C, SLC16A7 ADORA2B 1235/4885SMN1; SMN2 3272/4885LMNA 2718/4885
US-20240237643-A1 COMPOSITIONS WITH VIRUCIDAL AND/OR ANTIVIRAL ACTIVITY ZC3HAV1, SAMHD1, ZC3HAV1L ADORA2B 2935/4885SMN1; SMN2 3187/4885LMNA 2563/4885
US-20240173227-A1 A FRAGRANCE MIXTURE CONTAINING ISOCITRONELLOL IPO5, OR51E2, FDFT1 ADORA2B 4804/4885SMN1; SMN2 4173/4885LMNA 3949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.