Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acefylline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 6/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acefylline SCHEMBL5493561 | 1.00 | ADORA2B (0.85) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| Acefylline SCHEMBL18191994 | 0.92 | ADORA2B (1.00) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| Acefylline SCHEMBL308514 | 0.92 | ADORA2B (1.00) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| Acefylline SCHEMBL8402147 | 0.91 | ADORA2B (0.97) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| Acefylline SCHEMBL1173152 | 0.87 | ADORA2B (0.89) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| Acefylline SCHEMBL17204841 | 0.84 | ADORA2B (0.84) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| Acefylline SCHEMBL8976498 | 0.84 | ADORA2B (0.66) | ADORA2BSMN1; SMN2KMT2AMEN1RXFP1 | |
| SCHEMBL17163939 | 0.81 | ADORA2B (0.78) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL11531219 | 0.81 | ADORA2B (0.78) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL18166629 | 0.80 | RXFP1 (0.80) | ADORA2BSMN1; SMN2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 323 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118948925-A | A composition extracted from Celastrus orbiculatus plant for treating cancer, and its preparation method and application | 广西仙手棋药业科技有限公司 | 2024-11-15 | — | — | CN | claimed |
| US-20200182859-A1 | HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION | UNIVERSITE DE FRIBOURG (CH) | 2020-06-11 | — | — | US | claimed |
| EP-3634421-A1 | HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION | Université de Fribourg (CH) | 2020-04-15 | — | — | EP | claimed |
| WO-2019203511-A9 | PHARMACEUTICAL COMPOSITION COMPRISING DEOXYCHOLIC ACID | 주식회사 펜믹스 | 2019-12-26 | — | — | WO | claimed |
| WO-2019203511-A1 | PHARMACEUTICAL COMPOSITION COMPRISING DEOXYCHOLIC ACID | 주식회사 펜믹스 | 2019-10-24 | — | — | WO | claimed |
| US-20190314388-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DEOXYCHOLIC ACID | PENMIX LTD. (KR) | 2019-10-17 | — | — | US | claimed |
| WO-2018224650-A1 | HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION | UNIVERSITE DE FRIBOURG (CH) | 2018-12-13 | — | — | WO | claimed |
| EP-3412294-A1 | HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION | Universite De Fribourg (CH) | 2018-12-12 | — | — | EP | claimed |
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| EP-2571499-A1 | PHARMACEUTICAL COMPOSITION COMPRISING N- ACETYLCYSTEINE AND A XANTHINE | Bilgic, Mahmut (TR) | 2013-03-27 | — | — | EP | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| WO-1998030900-A2 | SCREENING METHOD FOR COMPOUNDS ACTIVE IN TREATING MYOPIA AND HYPERMETROPIA | KLAUS TRIER APS (DK) | 1998-07-16 | — | — | WO | claimed |
| EP-0480934-B1 | A SLIMMING PHARMACEUTICAL COMPOSITION | NYCOMED DAK AS (DK) | 1994-06-29 | — | — | EP | claimed |
| EP-0270305-B1 | SPHEROIDS | Euroceltique S.A. (LU) | 1993-01-20 | — | — | EP | claimed |
| EP-0480934-A1 | A SLIMMING PHARMACEUTICAL COMPOSITION. | DAK LAB AS (DK) | 1992-04-22 | — | — | EP | claimed |
| US-5091189-A | Tablet contains 3-alkylxanthine, hydrophilic or hydrophobic polymers, and wax from the group consists of polyalkylene glycol | EUROCELTIQUE S.A. (LU) | 1992-02-25 | — | — | US | claimed |
| WO-1991000730-A1 | A SLIMMING PHARMACEUTICAL COMPOSITION | DAK-LABORATORIET A/S (DK) | 1991-01-24 | — | — | WO | claimed |
| US-4844910-A | CONTROLLED RELEASE OF THEOPHYLLINE DERIVATIVES | EUROCELTIQUE, S.A. (LU) | 1989-07-04 | — | — | US | claimed |
| EP-0270305-A2 | Spheroids | Euroceltique S.A. (LU) | 1988-06-08 | — | — | EP | claimed |