Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.49 |
| ▸ | JAK1 | P23458 | 8/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | ATR | Q13535 | 4/20 | 0.41 |
| ▸ | PDE9A | O76083 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30853311 | 0.78 | PDE9A (0.47) | JAK2JAK1JAK3PDE9A | |
| SCHEMBL31359330 | 0.74 | JAK1 (0.43) | JAK2JAK1JAK3PDE9A | |
| SCHEMBL12385233 | 0.69 | JAK1 (0.69) | JAK2JAK1JAK3 | |
| SCHEMBL31359322 | 0.68 | TNKS (0.46) | JAK2JAK1JAK3PDE9A | |
| SCHEMBL24968162 | 0.66 | ALDH1A1 (0.50) | — | |
| SCHEMBL2104894 | 0.66 | JAK2 (1.00) | JAK2JAK1JAK3 | |
| SCHEMBL9953321 | 0.66 | JAK1 (0.70) | JAK2JAK1JAK3 | |
| SCHEMBL31359324 | 0.66 | ALDH1A1 (0.37) | JAK2JAK1JAK3 | |
| SCHEMBL22518623 | 0.66 | LRRK2 (0.47) | JAK1ATRIDO1 | |
| SCHEMBL12384975 | 0.65 | JAK1 (1.00) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |