Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27186371 | 0.75 | SMN1; SMN2 (0.43) | PIK3CAPIK3CDPIK3CBPDE10APIK3CG | |
| SCHEMBL27186190 | 0.71 | ALDH1A1 (0.41) | PIK3CAPIK3CDPIK3CBMTORKMT2A | |
| SCHEMBL29844203 | 0.71 | ALDH1A1 (0.41) | PIK3CAPIK3CDPIK3CBMTORKMT2A | |
| SCHEMBL21500052 | 0.69 | LRRK2 (0.49) | PIK3CAPDE10AFYNPDE5APDE6A | |
| SCHEMBL19950255 | 0.68 | BRD4 (0.40) | — | |
| SCHEMBL30070507 | 0.68 | BRD4 (0.40) | — | |
| SCHEMBL4996432 | 0.67 | LMNA (0.68) | PIK3CAPIK3CDPIK3CBKMT2AMEN1 | |
| SCHEMBL26769922 | 0.67 | KDM4E (0.64) | PIK3CAPIK3CDPIK3CBPDE10AKMT2A | |
| SCHEMBL29168322 | 0.66 | TRPM8 (0.42) | PIK3CAPIK3CDPIK3CBPDE10ATRPM8 | |
| SCHEMBL11218577 | 0.66 | CYP2C19 (0.47) | PDE10ATRPM8MTORKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |